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LYME DISEASE TOP MEDICAL EXPERTS ON
REASONS WHY LYME IS CHRONIC AND PERSISTS:

Survival mechanisms of B. burgdorferi persistence include:

“Immune evasion via physical seclusion within immunologically protected tissue sites such as:
 
the CNS [brain], 
 
joints,
 
eyes, 
 
collagen-rich tissues, 
 
[misc] cells,
 
biofilms; 
 
alterations in outer surface protein (OSP) profiles ... [by altering outer parts],
 
phasic variations, 
 
immune modulation via alterations in complement, neutrophil and dendritic [brain] cell functioning, 
 
changes in cytokine and chemokine levels” 

Shor S., Green C., Szantyr B., Phillips S., Liegner K., Burrascano J.J., Jr., Bransfield R., Maloney E.L. Chronic Lyme Disease: An Evidence-Based Definition by the ILADS Working Group. Antibiotics. 2019;8:269. doi: 10.3390/antibiotics8040269.

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