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TB006 (TrueBinding): An Inflammation-First Monoclonal Antibody Strategy for Alzheimer’s Disease

TB006 is an investigational monoclonal antibody from TrueBinding that targets galectin-3, aiming to reduce amyloid aggregation and neuroinflammation in Alzheimer’s disease. Early Phase 2a data show trends toward slowed clinical decline and some cognitive improvement, and it is currently accessible mainly through the FDA Expanded Access Program. This is the first allopathic treatment ever to […]

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Detailed Anti-Inflammatory Options And Research Options

Natural Anti-Inflammatory Agents Ranked By Pathway I would not rank these simply from “strongest” to “weakest,” because different compounds affect different inflammatory pathways. A more scientifically useful ranking is by dominant pathway: NF-κB, NLRP3 inflammasome, TNF-α/IL-6, COX/LOX, Nrf2, AMPK/SIRT1, specialized pro-resolving mediators, gut-immune signaling, mast cells, and neuroinflammation. Evidence grading: A = substantial human RCT/meta-analysis

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James L. Schaller, MD, MAR
List Of Inflammation Options With Different Levels Of Evidence

A research-based master list of anti-inflammatory interventions, it helps to separate natural compounds, lifestyle/physiologic interventions, and medical/pharmacologic treatments. “Best” depends strongly on the disease and inflammatory pathway; suppressing inflammation broadly is not always beneficial. High-Value Anti-Inflammatory Options Category Intervention Major anti-inflammatory activity / target Evidence strength Natural Curcumin/curcuminoids ↓ NF-κB, COX-2, TNF-α, IL-1β, IL-6; NLRP3

James L. Schaller, MD, MAR
List Of Inflammation Options With Different Levels Of Evidence
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Arctigenin

Health-Benefit Research In Humans, Mice, Rats, And Other Mammalian Models

Arctigenin (AG) is a dibenzylbutyrolactone lignan found particularly in the fruit/seeds of Arctium lappa L. (burdock). It is the aglycone of arctiin. Mammalian research reports anti-inflammatory, neuroprotective, metabolic, anticancer, vascular, antiviral, and immunomodulatory actions. However, an important distinction is necessary: most therapeutic evidence is preclinical. Human interventional evidence is limited, with the most notable study

Arctigenin

Health-Benefit Research In Humans, Mice, Rats, And Other Mammalian Models
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Top Lyme Expert Doctor & Author Offers
An Excerpt From Our Sept/ 2026 Herb Book

Sample herbs killing Lyme disease. In a test-tube study, some natural treatments have a good ability to kill Lyme…. Researchers found that seven herbal extracts at only 1% potency killed Lyme effectively. These potent treatments were: Polygonum cuspidatum root (Japanese knotweed) Uncaria tomentosa (Cat’s Claw or Samento) Cryptolepis sanguinolenta Scutellaria baicalensis (Chinese skullcap) Juglans nigra

Top Lyme Expert Doctor & Author Offers
An Excerpt From Our Sept/ 2026 Herb Book
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This Or That Treatment “Almost Killed Me!” You?
Missing The Infection Realities And Self As A Medical Model

Possums. With Lyme, Bartonella, and Babesia, your body has so many variables that you are likely to have an unusual reaction to something. I assume this and therefore have no universal protocols for all humans on earth. They are casually sold by those who overwrite your mind to be adored or who experienced healing for

This Or That Treatment “Almost Killed Me!” You?
Missing The Infection Realities And Self As A Medical Model
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Author Of The Biofilms 2014 Top Book
Sample Overview Of Biofilms
(Not Merely In Lyme Disease And Bartonella)

27 Agents Or Agent Classes With Antibiofilm Activity Important distinction: only a minority have strong evidence for treating established biofilm infections in humans. Many are useful only at specific sites—implants, catheters, wounds, lungs, sinuses, oral cavity, or root canals—and some remain preclinical. In most deep infections, drainage, debridement, or removal of infected hardware is more

Author Of The Biofilms 2014 Top Book
Sample Overview Of Biofilms
(Not Merely In Lyme Disease And Bartonella)
Read More »

Dr. Eva Sapi’s Research On Borrelia, Biofilms, And Cellular Oncology

Dr. Eva Sapi, Chair of the Department of Biology and Environmental Sciences at the University of New Haven, has led notable research at the intersection of Borrelia burgdorferi (the Lyme disease bacterium), biofilm formation, and cellular oncology. Her laboratory’s work explores how persistent bacterial structures and intracellular infections may influence host tissue environments, inflammatory pathways,

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Haystead receives inaugural Neil L. Spector, MD, Legacy Award for Transformational Lyme and Tick-Borne Disease Research

Timothy Haystead, PhD, professor of pharmacology and cancer biology, has been honored with the inaugural Neil L. Spector, MD, Legacy Award for Transformational Lyme and Tick-Borne Disease Research, from the Bay Area Lyme Foundation.   The award is the foundation’s highest scientific honor, recognizing bold, rigorous, translational research that moves patients closer to answers. Haystead was honored for his research

Haystead receives inaugural Neil L. Spector, MD, Legacy Award for Transformational Lyme and Tick-Borne Disease Research Read More »

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