MORE BASICS ON SAM-e or SAMe
1. Sam-e is routinely prescribed in Europe for decades and gaining popularity in the United States as a dietary supplement since 1998–1999, SAMe has been proposed for many medical conditions, particularly depressive disorders [30].
2. SAMe has been widely studied compared with other food supplement ingredients, and an impressive body of literature from the last few decades suggests its antidepressant efficacy [31].
3, SAMe can cross the blood–brain barrier (BBB) from an oral dose, resulting in increased CSF levels…
4. The research shows oral SAMe in the dose range of 200–1600 mg/day is superior to placebo and as effective as TCAs (older tricyclic antidepressants) in alleviating different types of depression.
5. SAMe has been reported to have a faster onset of action than conventional antidepressant agents, and it may potentiate the therapeutic response of these drugs [30]. Table 1 summarizes the clinical trials, illustrating the effects of SAMe in depressive disorders.
***Schaller-we use as an augmenting treatment
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Ullah H, Khan A, Rengasamy KRR, Di Minno A, Sacchi R, Daglia M. The Efficacy of S-Adenosyl Methionine and Probiotic Supplementation on Depression: A Synergistic Approach. Nutrients. 2022 Jul 1;14(13):2751. doi: 10.3390/nu14132751. PMID: 35807931; PMCID: PMC9268496.