1. Erythema Migrans Rash
Reference: Steere AC, et al. The clinical evolution of Lyme arthritis. Ann Intern Med. 1983;99(1):76-82.
Reference: Wormser GP, et al. The clinical assessment, treatment, and prevention of Lyme disease. Clin Infect Dis. 2006;43(9):1089-1134.
2. Expanding Annular Rash
Reference: Steere AC, et al. Lyme disease. N Engl J Med. 2001;345(2):115-125.
3. Central Clearing in Rash
Reference: Hu L. Lyme disease. Ann Intern Med. 2016;164(9):ITC65-ITC80.
4. Warm Skin at Rash Site
Reference: CDC. Signs and Symptoms of Untreated Lyme Disease. Centers for Disease Control and Prevention.
5. Fatigue
Reference: Steere AC, et al. Lyme disease. N Engl J Med. 2001;345(2):115-125.
6. Fever
Reference: Wormser GP, et al. Clin Infect Dis. 2006;43(9):1089-1134.
7. Chills
Reference: CDC. Signs and Symptoms of Untreated Lyme Disease.
8. Headache
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
9. Neck Stiffness
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
10. Muscle Aches (Myalgias)
Reference: Wormser GP, et al. Clin Infect Dis. 2006;43(9):1089-1134.
11. Joint Aches (Arthralgias)
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
12. Swollen Lymph Nodes
Reference: CDC. Signs and Symptoms of Untreated Lyme Disease.
13. Malaise
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
14. Rash at Other Body Sites
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
15. Multiple Erythema Migrans Lesions
Reference: Wormser GP, et al. Clin Infect Dis. 2006;43(9):1089-1134.
16. Facial Palsy
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
17. Bell’s Palsy-Like Weakness
Reference: CDC. Lyme Disease Symptoms and Signs.
18. Meningitis
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
19. Radiculoneuritis
Reference: Wormser GP, et al. Clin Infect Dis. 2006;43(9):1089-1134.
20. Peripheral Neuropathy
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
21. Shooting or Stabbing Nerve Pain
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
22. Numbness
Reference: CDC. Lyme Disease Symptoms and Signs.
23. Tingling
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
24. Burning Pain
Reference: Wormser GP, et al. Clin Infect Dis. 2006;43(9):1089-1134.
25. Brain Fog
Reference: Marques A. Lyme neuroborreliosis. Continuum (Minneap Minn). 2015;21(6):1737-1750.
26. Difficulty Concentrating
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
27. Memory Problems
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
28. Sleep Disturbance
Reference: Marques A. Continuum. 2015;21(6):1737-1750.
29. Insomnia
Reference: CDC. Lyme Disease Symptoms and Signs.
30. Mood Changes
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
31. Irritability
Reference: Marques A. Continuum. 2015;21(6):1737-1750.
32. Depression
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
33. Anxiety
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
34. Photophobia
Reference: Marques A. Continuum. 2015;21(6):1737-1750.
35. Visual Blurring
Reference: CDC. Lyme Disease Symptoms and Signs.
36. Eye Pain
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
37. Conjunctivitis
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
38. Ear Pain
Reference: CDC. Lyme Disease Symptoms and Signs.
39. Tinnitus
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
40. Vertigo
Reference: Marques A. Continuum. 2015;21(6):1737-1750.
41. Dizziness
Reference: CDC. Lyme Disease Symptoms and Signs.
42. Palpitations
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
43. Lightheadedness
Reference: Wormser GP, et al. Clin Infect Dis. 2006;43(9):1089-1134.
44. Syncope
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
45. Lyme Carditis
Reference: Besant G, et al. An emergency department’s experience of Lyme carditis. J Emerg Med. 2018;54(3):e31-e35.
46. Atrioventricular Block
Reference: CDC. Lyme Carditis.
47. Shortness of Breath
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
48. Chest Pain
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
49. Exercise Intolerance
Reference: Marques A. Continuum. 2015;21(6):1737-1750.
50. Joint Swelling
Reference: Steere AC, et al. The clinical evolution of Lyme arthritis. Ann Intern Med. 1983;99(1):76-82.
51. Knee Swelling
Reference: CDC. Lyme Arthritis.
52. Migratory Joint Pain
Reference: Wormser GP, et al. Clin Infect Dis. 2006;43(9):1089-1134.
53. Arthritis
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
54. Recurrent Arthritis
Reference: Steere AC, et al. Ann Intern Med. 1983;99(1):76-82.
55. Limited Joint Range of Motion
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
56. Tendon Pain
Reference: CDC. Lyme Disease Symptoms and Signs.
57. Muscle Weakness
Reference: Marques A. Continuum. 2015;21(6):1737-1750.
58. Stiff Muscles
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
59. Back Pain
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
60. Jaw Pain
Reference: CDC. Lyme Disease Symptoms and Signs.
61. Sensitivity to Touch
Reference: Marques A. Continuum. 2015;21(6):1737-1750.
62. Tremor
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
63. Seizures
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
64. Poor Coordination
Reference: CDC. Lyme Disease Symptoms and Signs.
65. Gait Instability
Reference: Marques A. Continuum. 2015;21(6):1737-1750.
66. Sleepy/Daytime Somnolence
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
67. Sweats
Reference: CDC. Signs and Symptoms of Untreated Lyme Disease.
68. Fever With Relapsing Pattern
Reference: Wormser GP, et al. Clin Infect Dis. 2006;43(9):1089-1134.
69. Loss of Appetite
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
70. Nausea
Reference: CDC. Lyme Disease Symptoms and Signs.
71. Abdominal Pain
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
72. Diarrhea
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
73. Facial Numbness
Reference: Marques A. Continuum. 2015;21(6):1737-1750.
74. Eye Movement Abnormalities
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
75. Hearing Changes
Reference: CDC. Lyme Disease Symptoms and Signs.
76. Cognitive Slowing
Reference: Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
77. Word-Finding Difficulty
Reference: Marques A. Continuum. 2015;21(6):1737-1750.
78. Sensory Hypersensitivity
Reference: Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
79. Prolonged Symptoms After Treatment
Reference: Klempner MS, et al. Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. N Engl J Med. 2001;345(2):85-92.
80. Post-Treatment Lyme Disease Syndrome-a Debate if Ongoing Infection, Debris, or Both. I Believe Definitely Both.
Reference: Marques A. Lyme disease: a review. Curr Allergy Asthma Rep. 2010;10(1):13-20.
Key References Used Repeatedly
Steere AC, et al. N Engl J Med. 2001;345(2):115-125.
Wormser GP, et al. Clin Infect Dis. 2006;43(9):1089-1134.
Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80.
CDC Lyme disease pages.
Marques A. Continuum. 2015;21(6):1737-1750.