Artesunate has been reported to “possibly” be of use. against Babesia. My advice is to read our millions in self funded research and try to move past 2005 work we did that was quite definitive.
There is no first line treatment if you are trying to avoid relapse and resistance. I have already repeatedly addressed the 10ml Babesia cure with the yellow pain atovaquone which has no impact on 50% of Babesia. And we have books on the dose of azithromycin required to have any effect on Babesia. HINT: It is not 250 mg twice a day
And the atovaquone recently prescribed by a “Babesia-literate” physician was in the form of a tablet and not a liquid so it will kill malaria but not Babesia. That tablet is 250/100 mg and I use it for the second ingredient, proguanil and not the hard poorly absorbed atovaquone.
We do not get involved in species battles of human Babesia because I certainly doubt most human Babesia is microti, but will let the dust settle. Treating differently based on species assumes we are 30 years ahead in knowledge than we are.
Artemisinin is useful to start if you are highly sensitive to medicines, allergens or have mast cell activation syndrome.
Tafenoquine/primaquine-you must check a lab called a G6PD and if you are in the normal range these are good treatment options I published in 2006.
The idea that any one treatment is curative has been addressed repeatedly in books and elsewhere.