First, it’s us in Babesia and malaria is discussed in the next post.
The legal use of peptides varies profoundly from nation to nation. Discuss legal use with your local doctor.
Basics:
Human cathelicidin LL-37 is the only member of the cathelicidin family of antimicrobial peptides in humans, derived from the cleavage of hCAP-18. Produced by immune and epithelial cells, it acts as a broad-spectrum, cationic, amphipathic peptide that kills bacteria, viruses, and fungi. [Since it has effects against malaria, it might treat Babesia, but I doubt and a single thing kills Babesia except for one essential oil in our 2023 Herbs/Essential oils book] LL-37 plays a crucial role in innate immunity by neutralizing LPS, modulating inflammation, and promoting wound healing.
LL-37 Key Actions:
- Antimicrobial Action: It destroys pathogens by inserting into their membranes and breaking them apart.
- Immune Regulation: It acts as an “alarm” to attract immune cells to infection sites and acts as an immunomodulator.
- Clinical Significance: LL-37 is linked to inflammatory skin disorders (like psoriasis), and its dysfunction can contribute to autoimmune diseases (e.g., lupus) and cancer progression.
- Structure: It consists of 37 amino acids
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Research Areas: It is heavily studied for potential therapeutic uses in treating antibiotic-resistant infections and for wound healing.
While it has protective roles, excessive levels can lead to tissue damage, such as inducing symptoms of rosacea.