Here is a very short sample showing this issue from the American Journal of Psychiatry.
- Depression and inflammation fuel one another.
- Inflammation can cause depression. This is one reason we use the best inflammation chemicals lab in North America.
- Some depression makes negative inflammation chemicals (cytokines) surge in some situations.
- Inflammation is not the only cause of depression, or our 80 solutions book, Destroy Depression (Jan. 30, 2026) would have been done in a day. Obesity, trauma, infections, impaired hormones, sudden loss, high duration caretaker roles of the ill, and 250 medical things and other non-medical things can promote it
- Infections, high stress, pain, divorce, poor food choices long term, and many other things, can lead to exaggerated or prolonged inflammatory responses. high inflammation over time promotes biological depression.
- I have never seen another doctor locally use a prebiotic, probiotic or post biotic when prescribing antibiotics. The 100 trillion bacteria and the intestinal wall permeability, also promotes inflammation. Your 30 feet of sensitive gut tissue can be harmed even if you do not notice it happening.
- Do those with the most mood training target and evaluate inflammation in a depressed person?
- Basic ideas to target depression with inflammation include "cytokine antagonists, omega-3 fatty acids, celecoxib, and exercise that is anti-inflammatory." In 2026 we can do much better and build on these sample ideas.
- If both heightened inflammation and depression exist, treat both. Agree.
Kiecolt-Glaser JK, Derry HM, Fagundes CP. Inflammation: depression fans the flames and feasts on the heat. Am J Psychiatry. 2015 Nov 1;172(11):1075-91. doi: 10.1176/appi.ajp.2015.15020152. Epub 2015 Sep 11. PMID: 26357876; PMCID: PMC6511978