A Breakthrough way to detect Borrelia-related infection, and an answer to non-diagnosed ill people
Tick-borne infections are increasing globally—Lyme disease is among the most prevalent vector borne infection in the U.S. and Europe and is reaching epidemic levels (Kugeler et al. 2015; Sykes et al. 2014). While most ticks have the capacity to transmit a number of pathogens that cause human disease, Lyme disease is the most widely known tick-borne disease and is caused by bacteria of the genus Borrelia; typically Borrelia burgdorferi which are gram-negative spirochete bacteria. Borrelia are divided into "genospecies"; the most common include B. burgdorferi sensu stricto, B. garinii, B. afzelii, B. spielmanii, B. bavariensis and the newly identified B. miyamotoi. The overall high failure rate of tick-borne infection (TBI)-related testing underscores the necessity for novel approaches, i.e. not relying on serology and two-tier testing.