If this is possible, you must do the following labs.
- ANTIBODIES AGAINST NEURONS -USING THE CUNNINGHAM PANEL. Quest and LabCorp are poor at detecting antibodies against parts of neurons.
- Testing for Lyme, tick-borne relapsing fever, Babesia and Bartonella. Use as many expert labs as possible.
- LH-14 cytokine levels from Radiance labs
- Allergy testing
- Etc.
Biol Psychiatry. 2001 Oct 15;50(8):56677.
Antibodies against neural, nuclear, cytoskeletal, and streptococcal
epitopes in children and adults with Tourette's syndrome,
Sydenham's chorea, and autoimmune disorders.
Morshed SA , Parveen S, Leckman JF, Mercadante MT, Bittencourt Kiss MH, Miguel EC, Arman A, Yazgan Y,
Fujii T, Paul S, Peterson BS, Zhang H, King RA, Scahill L, Lombroso PJ.
Erratum in
Biol Psychiatry 2001 Dec 15;50(12): following 1009.
Abstract
Some cases of Tourette's syndrome (TS) are hypothesized to be caused by autoantibodies that develop in response to a preceding group A beta hemolytic streptococcal infection.
To test this hypothesis, we looked for the presence ot total and IgG antibodies against neural, nuclear, cytoskeletal and streptococcal epitopes using indirect immunofluorescent assays and
Western blot techniques in three patient groups: TS (n = 81), SC (n = 27), and a group of autoimmune disorders (n = 52) and in normal controls (n = 67). Subjects were ranked after titrations
of autoantibodies from 0 to 227 according to their level of immunoreactivity. TS patients had a significantly higher mean rank for total antineural and antinuclear antibodies, as well as antistreptolysin O titers. However, among children and adolescents, only the total antinuclear antibodies were increased in TS patients compared to age matched controls.
Compared to SC patients, TS patients had a significantly lower mean rank for total and IgG class antineural antibodies, significantly lower IgG class anticytoskeletal antibodies, and a substantially higher rank for total antinuclear antibodies. Compared to a mixed group of autoimmune disorders,the TS patients had a significantly lower mean rank for total and IgG class antineuronal antibodies, total and IgG class antinuclear antibodies, IgG class anti cytoskeletal antibodies, and a significantly higher rank for antistreptococcal antibodies. TS patients had significantly higher total antineural and antinuclear antibody levels than controls. Their relation to IgG class antineural and antinuclear antibodies, markers for prior streptococcal infection, and other clinical characteristics, especially chronological age, was equivocal.
PMID: 11690591