Dr James Schaller
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I have published on SAM-e and other treatments for depression in some of the largest psychiatric journals in the world. SAM-e is a stunningly powerful treatment for depression that does not undermine sexual function, and improves three neurotransmitters. SAM-e is made in the body naturally, but as we age, blood levels fall.


A European, pharmaceutical quality SAM-e found to promote healthy mood, liver and joint function.

A powerful, natural nutrient, S-adenosyl methionine (SAM-e) promotes healthy mood, liver and joint function.

NSI® SAM-e is pharmaceutical quality, full potency, and stabilized. SAM-e supplements contain amounts of both the active SS form and the inactive RS form. NSI SAM-e undergoes a natural process of microbiological fermentation, and is then specially processed without solvents. This process ensures an active SS level of 68-80%, the highest concentration available.

SAM-e supplementation may benefit aging people, as they are prone to experience joint discomfort.

SAM-e is believed to raise the levels of specific neurotransmitters, especially that of dopamine, which is important for mood regulation.

SAM-e boosts natural antioxidant levels, and may provide benefits for liver health. In the liver, SAM-e supports the improved flow of bile and replenishes important antioxidants.

The typical SAM-e dosage is 400-800 mg daily for promoting a healthy mood, liver and joints. Some depressed patients do better with a higher dose used together with a B-Complex vitamin since SAM-e uses these vitamins. It should be consumed as a tablet that is enteric-coated and is in the stabilized and standardized form. As SAM-e is 50% elemental, a product must provide 800 mg gross to equal 400 mg elemental, thereby making it beneficial. NSI® SAM-e 400 mg (from 800 mg gross) contains 30 enteric-coated tablets. Some companies sell packets of only 20 tablets—do not be fooled!

Did You Know?

All NSI supplements are packaged in HDPE (High Density Polyethylene) bottles. These bottles keep moisture vapor out, protecting the freshness and integrity of their contents, and are 400% more effective compared other brands currently using PET (Polyethylene Terephthalate) bottles. HDPE bottles do not break as glass can and are recyclable so please recycle them.

LINK TO TRUE WHOLESALE SAM-e: www.vitacost.com/NSI/Same


Dr. Schaller is on the medical board of Vitacost.com, but receives nothing for individual purchase. It is where he buys 95% of his nutrients for his entire clan. He can buy at a "discount" or "wholesale" as a medical professional from hundreds of companies.

Yet he finds no one can touch these top brands for quality and price. These are real wholesale prices, and not the "game prices" one finds all over the Internet.

Please compare standardization, mg, pill number, source of the high quality ingredients, and one low one size fits all shipping cost and Dr. Schaller feels this is THEE top location for most of your health needs. Some try to compete. Dr. Schaller prefers this first place company. He has also been pleased that the NSI brand of Vitacost.com has tried to rely on solid research and not speculative health inventions based on poor studies that some companies use.

Dr. Schaller is humbled and proud of Vitacost.com.


Individuals using prescribed medications, such as antidepressants, including Serotonin Re-Uptake Inhibitors and MAO Inhibitors, should consult a physician before using. Individuals with Parkinson's disease, bipolar disorder or manic depression should not use SAM-e. Do not use if pregnant or nursing. Do not exceed recommended dose. SAM-e may cause gastrointestinal upset in some persons.

If you experience discomfort, discontinue use.


The FDA has not evaluated these statements. These products are not intended to diagnose, treat, cure, or prevent any disease.

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