Lyme Disease and Multiple Sclerosis (Ms)
The research and patient reports seem to show three things exist:
Any one who does not consider all these options is naive.
And a single ELISA or Western Blot that is negative in patients with a perfect history of repeated bulls-eye rashes with deer in the back yard and joint pain are clueless about dummied down testing to have the "correct" number of positives. Further, based on my Bartonella textbook and other research, Bartonella can turn down ELISA and Western Blot results. Bartonella is far more common than Lyme.
Currently deer are exploding like locusts and are so massive in number they cause immense car accidents. And this is nothing compared to the deer tick exposure the tens of millions of Americans.
I deeply respect my friends that try to protect animals such as the hundreds of at risk species all around the world. Thank you. However, deer are modern day rats and are totally out of control.
Sample MS Research and Lyme Disease
Chronic Lyme borreliosis at the root of multiple sclerosis—is a cure with antibiotics attainable?
Apart from its devastating impact on individuals and their families, multiple sclerosis (MS) creates a huge economic burden for society by mainly afflicting young adults in their most productive years. Although effective strategies for symptom management and disease modifying therapies have evolved, there exists no curative treatment yet. Worldwide, MS prevalence parallels the distribution of the Lyme disease pathogen Borrelia (B.) burgdorferi, and in America and Europe, the birth excesses of those individuals who later in life develop MS exactly mirror the seasonal distributions of Borrelia transmitting Ixodes ticks. In addition to known acute infections, no other disease exhibits equally marked epidemiological clusters by season and locality, nurturing the hope that prevention might ultimately be attainable. As minocycline, tinidazole and hydroxychloroquine are reportedly capable of destroying both the spirochaetal and cystic L-form of B. burgdorferi found in MS brains, there emerges also new hope for those already afflicted. The immunomodulating anti-inflammatory potential of minocycline and hydroxychloroquine may furthermore reduce the Jarisch Herxheimer reaction triggered by decaying Borrelia at treatment initiation. Even in those cases unrelated to B. burgdorferi, minocycline is known for its beneficial effect on several factors considered to be detrimental in MS. Patients receiving a combination of these pharmaceuticals are thus expected to be cured or to have a longer period of remission compared to untreated controls. Although the goal of this rational, cost-effective and potentially curative treatment seems simple enough, the importance of a scientifically sound approach cannot be overemphasised. A randomised, prospective, double blinded trial is necessary in patients from B. burgdorferi endemic areas with established MS and/or Borrelia L-forms in their cerebrospinal fluid, and to yield reasonable significance within due time, the groups must be large enough and preferably taken together in a multi-centre study. [CSF TESTING OF LYME IS HIGHLY COMPLEX]
Fritzsche M. Med Hypotheses. 2005;64(3):438-48.
Dysarthria [Speech Disorder] As the Isolated Clinical Symptom of Borreliosis [Lyme Disease]. A Case Report
Abstract: This report presents a case of dysarthria due to hypoglossal nerve mono-neuropathy as the only consequence of neuroborreliosis. The 65-year-old man with a seven-months history of articulation disturbances was examined. The speech of the patient was slow and laboured. A slight weakness of the muscles of the tongue (left-side) was observed. The patient suffered from meningitis due to Borrelia burgdorferi infection in 1999 and initially underwent a successful antibiotic treatment. Detailed radiological investigation and psychological tests were performed and co-existing neurological diseases were excluded. To describe profile of speech abnormalities the dysarthria scale was designed based on S. J. Robertson Dysarthria Profile. There were a few disturbances found in self-assessment of speech, intelligibility, articulation, and prosody but especially in the morphology of the articulation muscles, diadochokinesis, the reflexes (in the mouth, larynx and pharynx). Needle EMG examination confirmed the diagnosis of mono-neuropathy of left hypoglossal nerve. The study confirms the fact that neuroborreliosis may evoke chronic consequences. [THESE CHRONIC FINDINGS MAY BE DUE TO RESIDUAL LYME WITH CO-INFECTIONS AND NOT MS AS SOME WOULD REASONABLY SUSPECT.]
Katarzyna Gustaw, Urszula Mirecka. Ann Agric Environ Med 2001, 8, 95-97.
The presence of anti-Borrelia burgdorferi antibodies in a group of multiple sclerosis patients in eastern Sicily. Preliminary data.
The authors evaluate the presence of anti-Borrelia burgdorferi antibodies in a group of polysclerotic patients of Eastern Sicily, in order to verify or dismiss a correlation between Borrelia infection and demyelinizing syndrome. 460 samples of serum were examined, of which 60 belonged to patients affected by definite multiple sclerosis; the other 400 were taken from a group of apparently healthy subjects. From the analysis of the data obtained it can be seen that of the 60 polysclerotic subjects examined, 12 equal to 20% [1/5th] were found to be positive for the presence of IgG anti-Borrelia burgdorferi, while in the control group 30 subjects were found to be positive, equal 7.5%.
Acta Neurol;1993 Aug;15(4):253-7.******
Diseases that mimic multiple sclerosis.
Because no one laboratory test is diagnostic of multiple sclerosis, evaluation involves careful exclusion of other possible diagnoses. Magnetic resonance imaging is a valuable tool in this process. Clues from a scan can confirm findings from the history and physical and laboratory examinations. Dr Scott compares typical findings of multiple sclerosis with those of the four diseases that are sometimes mistaken for this syndrome.
Scott TF. Postgrad Med. 1991 Jun;89(8):187-91.
Lyme disease sufferer spent years being misdiagnosed
BY CAIT MCINTYRE
Brenda Sterling-Goodwin believes she contracted Lyme disease about 10 years ago. Back then, she was a cat groomer and a veterinary technician.
Doctors in Nova Scotia doubted her condition. One neurologist told her she had multiple sclerosis. It's common, she says, for people with Lyme disease to be misdiagnosed as having multiple sclerosis, lupus, arthritis, or other illnesses with similar symptoms.
It wasn't until she saw the test results from California that she finally had confirmation she was suffering with the disease.
"(Lyme disease) affects everybody differently," says Sterling-Goodwin, a New Glasgow resident.
In her case, the disease has affected her mobility, especially. While she does prefer to walk, she sometimes uses a wheelchair. She's often in pain over the stiffness in her legs, and her feet are swollen to twice their normal size.
Lyme disease is transmitted by a blacklegged tick, after it has attached itself to the skin for 24 hours. Caused by a form of spirochete bacteria, it can be treated with antibiotics if caught early.
There have been eight confirmed cases of Lyme disease in the province since 2002. "But the only confirmed cases are the ones that meet Canadian standards, which are not the best," Sterling-Goodwin says.
Every three months, Sterling-Goodwin travels to XXXXX to see her doctor, but she sends him monthly faxes to update him on her condition while between visits. "There are not a lot of Lyme-literate doctors in Canada, unfortunately."
She says "early diagnosis and education" is key. She hopes the news of a Pictou County tick being discovered carrying the disease will heighten awareness.
She adds those removing ticks should exercise caution. Ticks should never be twisted, burned or squeezed. When removing ticks, always use tweezers and pull upwards, she says.
Neurological complications of Lyme borreliosis.
Lyme disease, like syphilis, a spirochetal infection, can appear with exacerbations and remissions in different stages. The clinical picture is marked by dermatological, neurological, rheumatic and cardiological complications. PNS complications appear in the second and third stage. Tick bite meningoradiculoneuritis neuritis (Garin-Bujadoux-Bannwarth-Syndrome), characterized by painful asymmetrical sensory and motor dysfunctions and inflamed CSF, is a typical manifestation of the second stage. Mononeuritis multiplex appearing in conjunction with acrodermatitis chronica atrophicans is a typical PNS manifestation of the third stage. CNS involvement may also occur in early and late stages of Lyme-Borreliosis, presenting as myelitis or progressive encephalomyelitis. Lyme-Borreliosis is a treatable condition, which should not be missed in the differential diagnosis of PNS and CNS disorders.
Meier C. Ital J Neurol Sci. 1992 Dec;13(9 Suppl 14):85-90.