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A comparison of two treatment regimens of
ceftriaxone in late Lyme disease

Blindness in Chronic Lyme Studies: Lets Count a Few Errors in the Study Below:

  1. 26-30% were not "clinically cured."
  2. Profound ignorance of the manner in which Lyme endotoxins make ill depending on genetic endotoxin excretion ability. Here we are told the 28-day treated patients had more "side effects." What a clinically eccentric read. "Side effects" are usually from onset treatment. They never consider the possibility the "side effects were causes by more lyme die-off and endotoxins. A sample of Lyme endotoxin material is at this link: www.personalconsult.com/articles/lymeendotoxins.html"
  3. No awareness is shown of the massive data on protective cystic forms of Lyme. In many folks that "improve" clinically, it is not because of full eradication, but due to the formation of inactive protective "walnut-like" cysts.

BACKGROUND: The optimal duration of treatment for patients with late Lyme disease is unresolved. METHODS: In a prospective, open label, randomized, multi-center study, a 14 day course of ceftriaxone was compared to 28 days of therapy. Entry criteria included objective abnormalities compatible with late Lyme disease and serologic reactivity to Borrelia burgdorferi. Randomization took place prior to obtaining serologic results. Clinical response was rated as cure; improvement; failure; or not assessable. RESULTS: Of the 201 patients randomized, 21 patients in the 14 day group and 37 in the 28-day group were excluded from the study for failure to meet serologic criteria. Of those who met serologic criteria, 80 patients received 14 days and 63 received 28 days of ceftriaxone. At time of last evaluation, there were 5 treatment failures in the 14 day group and none in the 28 day group (p = 0.07). Clinical cure rates were 76% for the 14 day group and 70% for the 28 day group (p = NS). Therapy was discontinued due to adverse events for a significantly greater proportion of patients in the 28-day group compared to the 14-day group (p < 0.02). CONCLUSIONS: Ceftriaxone for 14 days eradicated the signs and symptoms of late Lyme disease in the majority of evaluable patients. Although there were more failures in the 14-day group than in the 28-day group, this study did not have the power to determine if a clinical subset of patients may benefit from 28 days of therapy.

Dattwyer,RJ, Wormser GP, Rush TJ, Finkel MF, Schoen RT, Grunwaldt E, Franklin M, Hilton E, Bryant GL, Agger WA, Maladorno D. A comparison of two treatment regimens of ceftriaxone in late Lyme disease. Wien Klin Wochenschr. 2005 Jun;117(11-12):393-7.

This should offer hope to any young person wanting to do research in Lyme infections. It seems just about anyone with significant Lyme ignorance can get a grant these days.

Dedicated to the dead and the horribly ill. You are not forgotten.


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