Dr James Schaller
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True Lyme Experts Who Actually Treat Lyme Patients
Realize Tick-Born Infection is Very Complex

Lyme as a "Great Imitator"(Dr. Fallon: Columbia)

It is good to read that the North Carolina State Medical Board believes in open hearings and chats with the media. If I knew so little about the tick-borne illness in their state, I would ask for some education from the state clinical Lyme expert, Dr. Joseph Jemsek, a nationally respected expert in many infection areas. The state medical board of North Carolina, lead by Dr. Moffatt, seems to be a man with limited publications, or at least a search of PubMed could find little or nothing under his name and initials. So a Goggle search and PubMed search yields little research or advanced clinical publications of any consequence, while he attacks the prolific Dr. J. Jemsek in the media. One would hope this "openness" of the board would extend to Dr. Moffatt. One wonders how many patients he has treated with tick-born illness? Who travels to consult with him from distant states? I welcome any information about his research publications. I can not find anything.

Here is a Sample of a Simple Lyme Article

Genetic heterogeneity of Borrelia burgdorferi sensu lato in the southern United States based on restriction fragment length polymorphism and sequence analysis.

Lin T, Oliver JH Jr, Gao L, Kollars TM Jr, Clark KL.

Institute of Arthropodology and Parasitology, Department of Biology, Georgia Southern University, Statesboro, Georgia 30460-8056, USA.

Fifty-six strains of Borrelia burgdorferi sensu lato, isolated from ticks and vertebrate animals in Missouri, South Carolina, Georgia, Florida, and Texas, were identified and characterized by PCR-restriction fragment length polymorphism (RFLP) analysis of rrf (5S)-rrl (23S) intergenic spacer amplicons. A total of 241 to 258 bp of intergenic spacers between tandemly duplicated rrf (5S) and rrl (23S) was amplified by PCR. MseI and DraI restriction fragment polymorphisms were used to analyze these strains. PCR-RFLP analysis results indicated that the strains represented at least three genospecies and 10 different restriction patterns. Most of the strains isolated from the tick Ixodes dentatus in Missouri and Georgia belonged to the genospecies Borrelia andersonii. Excluding the I. dentatus strains, most southern strains, isolated from the ticks Ixodes scapularis and Ixodes affinis, the cotton rat (Sigmodon hispidus), and cotton mouse (Peromyscus gossypinus) in Georgia and Florida, belonged to Borrelia burgdorferi sensu stricto. Seven strains, isolated from Ixodes minor, the wood rat (Neotoma floridana), the cotton rat, and the cotton mouse in South Carolina and Florida, belonged to Borrelia bissettii. Two strains, MI-8 from Florida and TXW-1 from Texas, exhibited MseI and DraI restriction patterns different from those of previously reported genospecies. Eight Missouri tick strains (MOK-3a group) had MseI patterns similar to that of B. andersonii reference strain 21038 but had a DraI restriction site in the spacer. Strain SCGT-8a had DraI restriction patterns identical to that of strain 25015 (B. bissettii) but differed from strain 25015 in its MseI restriction pattern. Strain AI-1 had the same DraI pattern as other southern strains in the B. bissettii genospecies but had a distinct MseI profile. The taxonomic status of these atypical strains needs to be further evaluated. To clarify the taxonomic positions of these atypical Borrelia strains, the complete sequences of rrf-rrl intergenic spacers from 20 southeastern and Missouri strains were determined. The evolutionary and phylogenetic relationships of these strains were compared with those of the described genospecies in the B. burgdorferi sensu lato species complex. The 20 strains clustered into five separate lineages on the basis of sequence analysis. MI-8 and TXW-1 appeared to belong to two different undescribed genospecies, although TXW-1 was closely related to Borrelia garinii. The MOK-3a group separated into a distinct deep branch in the B. andersonii lineage. PCR-RFLP analysis results and the results of sequence analyses of the rrf-rrl intergenic spacer confirm that greater genetic heterogeneity exists among B. burgdorferi sensu lato strains isolated from the southern United States than among strains isolated from the northern United States. The B. andersonii genospecies and its MOK-3a subgroup are associated with the I. dentatus-cottontail rabbit enzootic cycle, but I. scapularis was also found to harbor a strain of this genospecies. Strains that appear to be B. bissettii in our study were isolated from I. minor and the cotton mouse, cotton rat, and wood rat. The B. burgdorferi sensu stricto strains from the south are genetically and phenotypically similar to the B31 reference strain.

[Basically, Lyme is very variable and present in many complex ways all over the south. Despite the nonsense that it does not exist outside some NE states. The southern forms are generally still related to basic Lyme--the B31 strain]

Journal of Cliical Microbiology. 2001 Jul;39(7):2500-7

PMID: 11427560 [PubMed - indexed for MEDLINE]

All italics, enlargements and bolding is by Dr. Schaller

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