Glutathione (GSH) More science: major detox pathways Phase I Phase II Phase III Key biochemical notes Full references
“Detoxification” is mainly liver plus renal/biliary excretion using these: Continue »
Below is a solid and serious list of major detoxification-related chemicals, enzymes, and transporters, with body sources and when they matter most. In biochemistry, detoxification mainly means: phase I biotransformation, phase II conjugation, and phase III transport/excretion. 1. Glutathione (GSH) 2. Glutathione S-transferases (GSTs) 3. Glutathione reductase 4. N-acetylcysteine (NAC) 5. Cysteine 6. Methionine 7. S-adenosylmethionine (SAMe) 8. Folate / 5-methyltetrahydrofolate (5-MTHF) 9. Vitamin
AN ADVANCED SUMMARY OF DETOX MEDICINE Continue »
Here are 20 things that support the body’s natural detoxification processes.Note: the body “detoxifies” primarily through the liver, kidneys, lungs, gut, skin, and lymphatic system—these are the main systems involved. Full references
BASIC SIMPLE “DETOXIFICATION” Continue »
A Top Lyme-Literate Practitioner With 30+ Years of Experience Looks at Venlafaxine (Effexor) and OCD Venlafaxine may be effective for OCD, including in patients who do not respond to SSRIs, with response rates ranging from 40% to 70% in clinical studies. Clinical Evidence Venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI), has been studied as an alternative to SSRIs for OCD. In
Lyme Disease Can Cause Severe OCD Continue »
This is a book on Natural Medicine. But here are Synthetic Options Top and Emerging Synthetic Anti-Inflammatory Drugs Small-molecule pharmaceuticals; biologic monoclonal antibodies are excluded. I have separated established agents from newer/emerging targeted molecules. Ranking is approximate because potency and usefulness depend heavily on the disease. JAK/TYK2, PDE4, BTK, NLRP3 and RIPK1 inhibition are among the most important areas of
Quotes From Book on Anti-Inflammation Treatments Natural Anti-Inflammatories Top 100 Natural Anti-Inflammatory Agents Approximate ranking by strength of human evidence, reproducibility, biologic plausibility, and clinical relevance. “Natural” does not imply safe, and biomarker lowering is not equivalent to demonstrated treatment of a specific inflammatory disease. Curcumin / turmeric (Curcuma longa) — Modulates NF-κB, COX-2, LOX, NLRP3, TNF-α, IL-1β and IL-6;
Lyme-Literate MD Offers Many Samples Continue »
Novel broad-spectrum candidates rather than standard drugs, #61–98 deserve a mention…. Especially quercetin, baicalein/baicalin, EGCG, curcumin, resveratrol, andrographolide, glycyrrhizin, berberine, lactoferrin, sulforaphane, fungal polysaccharides and β-glucans. Established antiviral = reproducible antiviral benefit has been demonstrated in humans, or the agent has a regulatory indication based on an accepted pathway such as the FDA Animal Rule. Clinical/limited = human data exist,
The human body utilizes a complex network of pathways to neutralize and eliminate toxins, primarily coordinated by the liver, kidneys, lungs, lymphatic system, and skin. Cytochrome P450 (Phase I Oxidation) The primary liver enzyme system that converts fat-soluble toxins into smaller, reactive intermediates. Glucuronidation (Phase II) Attaches glucuronic acid to toxins like drugs and bilirubin, making them water-soluble for excretion
20 Critical Detoxification Pathways Continue »
