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27 Agents Or Agent Classes With Antibiofilm Activity Important distinction: only a minority have strong evidence for treating established biofilm infections in humans. Many are useful only at specific sites—implants, catheters, wounds, lungs, sinuses, oral cavity, or root canals—and some remain preclinical. In most deep infections, drainage, debridement, or removal of infected hardware is more important than adding a “biofilm […]

Dr. Eva Sapi, Chair of the Department of Biology and Environmental Sciences at the University of New Haven, has led notable research at the intersection of Borrelia burgdorferi (the Lyme disease bacterium), biofilm formation, and cellular oncology. Her laboratory’s work explores how persistent bacterial structures and intracellular infections may influence host tissue environments, inflammatory pathways, and cancer cell behavior. 1.

Timothy Haystead, PhD, professor of pharmacology and cancer biology, has been honored with the inaugural Neil L. Spector, MD, Legacy Award for Transformational Lyme and Tick-Borne Disease Research, from the Bay Area Lyme Foundation.   The award is the foundation’s highest scientific honor, recognizing bold, rigorous, translational research that moves patients closer to answers. Haystead was honored for his research applying precision oncology techniques to

On Finding Causes And Treatments For Chronic Fatigue Syndrome (CFS) Years ago I was writing a book, “Are You Tired of Being Tired?” When I reached about 200 causes, I stopped writing that book. What Causes Fatigue? Common And Rare Causes Explained Fatigue occurs when normal physiological processes are disrupted — by infections, inflammation, metabolic changes, nerve sensitisation, or structural

A Top Expert Research Physician On Chronic Fatigue (CFS) When To Seek Medical Help ⚠ Sudden, severe fatigue that peaks within seconds to minutes ⚠ Fatigue accompanied by chest pain, shortness of breath, or neurological changes ⚠ Onset after trauma, head injury, or toxic exposure ⚠ Progressive worsening over days or weeks without a clear cause ⚠ Fatigue in a

A biotoxin is simply a toxic substance produced by a living organism. While many acute biotoxins exist in nature (like snake venom or spider venom), when clinical specialists discuss “biotoxins” in the context of chronic fatigue, Lyme disease, and immune dysregulation, they are usually referring to microscopic, lipid-soluble (fat-soluble) toxins. Because these specific biotoxins are fat-soluble, they can easily cross

Preventing glucose from ever being turned off in the body. It is profoundly inflammatory. A DEXA scan is a highly accurate method for measuring visceral fat, providing detailed insights into body composition and associated health risks. What Is Visceral Fat? Visceral fat is the type of fat that surrounds internal organs in the abdominal cavity, such as the liver, stomach,

It increases serious illness, and early death. Mortality Visceral adipose tissue (VAT), the fat stored around internal organs, is strongly linked to adverse cardio-metabolic profiles. Studies show that in adults ≤ 65 years, higher VAT area or volume is associated with an 11–98% increase in all-cause mortality risk. Mechanisms Of Risk Visceral fat acts like an endocrine organ, releasing hormones

Butyrate, a short-chain fatty acid produced by gut bacteria fermenting fiber, has a balancing effect on histamine. It acts as a mast cell stabilizer, suppressing the release of histamine by calming hyperactive immune cells. It also supports the intestinal lining, which is necessary for producing the enzyme that breaks down histamine. It is available as a supplement and as an