Lyme Disease

This is a book on Natural Medicine. But here are Synthetic Options Top and Emerging Synthetic Anti-Inflammatory Drugs Small-molecule pharmaceuticals; biologic monoclonal antibodies are excluded. I have separated established agents from newer/emerging targeted molecules. Ranking is approximate because potency and usefulness depend heavily on the disease. JAK/TYK2, PDE4, BTK, NLRP3 and RIPK1 inhibition are among the most important areas of […]

Quotes From Book on Anti-Inflammation Treatments Natural Anti-Inflammatories Top 100 Natural Anti-Inflammatory Agents Approximate ranking by strength of human evidence, reproducibility, biologic plausibility, and clinical relevance. “Natural” does not imply safe, and biomarker lowering is not equivalent to demonstrated treatment of a specific inflammatory disease. Curcumin / turmeric (Curcuma longa) — Modulates NF-κB, COX-2, LOX, NLRP3, TNF-α, IL-1β and IL-6;

Novel broad-spectrum candidates rather than standard drugs, #61–98 deserve a mention…. Especially quercetin, baicalein/baicalin, EGCG, curcumin, resveratrol, andrographolide, glycyrrhizin, berberine, lactoferrin, sulforaphane, fungal polysaccharides and β-glucans. Established antiviral = reproducible antiviral benefit has been demonstrated in humans, or the agent has a regulatory indication based on an accepted pathway such as the FDA Animal Rule. Clinical/limited = human data exist,

110 signs/symptoms table # Sign or Symptom Typical Frequency Reference 1 Erythema migrans rash Common Steere AC, et al. N Engl J Med. 2001;345(2):115-125. 2 Expanding rash Common Wormser GP, et al. Clin Infect Dis. 2006;43(9):1089-1134. 3 Central clearing rash Common Hu L. Ann Intern Med. 2016;164(9):ITC65-ITC80. 4 Warmth at rash site Common CDC. Signs and Symptoms of Untreated Lyme

1. Erythema Migrans Rash Reference: Steere AC, et al. The clinical evolution of Lyme arthritis. Ann Intern Med. 1983;99(1):76-82. Reference: Wormser GP, et al. The clinical assessment, treatment, and prevention of Lyme disease. Clin Infect Dis. 2006;43(9):1089-1134. 2. Expanding Annular Rash Reference: Steere AC, et al. Lyme disease. N Engl J Med. 2001;345(2):115-125. 3. Central Clearing in Rash Reference: Hu