Babesia and Bartonella: FISH Testing at IGeneX & TLab Positive FISH to negative FISH is not a cure. It is only a drop in numbers. A couple of expert Lyme disease doctors and scientists have taught that FISH testing is the way to determine if someone is positive or negative for Babesia and Bartonella. No. Look at this Bartonella slide, […]
Errors in the Use of FISH Testing Continue »
What? 🙂 The Father of Modern Bartonella Science, Dr. Edward Breitschwerdt, reports: “It can take up to six weeks to have enough cultured growth to enable a doctor, pathologist, or microbiologist to see Bartonella under a microscope.” Infectious disease doctors told a medical board this visualization is required to diagnose Bartonella. I would love to see them do that with
I would not be so sure. Infectious agents found in or transmitted through tick saliva: Detected somewhere in a tick is not equivalent to demonstrated in tick saliva. Yet it seems that for most biologically transmitted tick-borne pathogens, the salivary glands and saliva are central to transmission. Below are agents for which there is evidence of salivary gland involvement, saliva-assisted
Tick Saliva Can Pass Nothing Infectious Easily Continue »
Natural Anti-Inflammatory Agents Ranked By Pathway I would not rank these simply from “strongest” to “weakest,” because different compounds affect different inflammatory pathways. A more scientifically useful ranking is by dominant pathway: NF-κB, NLRP3 inflammasome, TNF-α/IL-6, COX/LOX, Nrf2, AMPK/SIRT1, specialized pro-resolving mediators, gut-immune signaling, mast cells, and neuroinflammation. Evidence grading: A = substantial human RCT/meta-analysis evidence; B = some human
Detailed Anti-Inflammatory Options And Research Options Continue »
A research-based master list of anti-inflammatory interventions, it helps to separate natural compounds, lifestyle/physiologic interventions, and medical/pharmacologic treatments. “Best” depends strongly on the disease and inflammatory pathway; suppressing inflammation broadly is not always beneficial. High-Value Anti-Inflammatory Options Category Intervention Major anti-inflammatory activity / target Evidence strength Natural Curcumin/curcuminoids ↓ NF-κB, COX-2, TNF-α, IL-1β, IL-6; NLRP3 modulation Human RCTs/meta-analyses Natural Omega-3
James L. Schaller, MD, MAR
List Of Inflammation Options With Different Levels Of Evidence Continue »
The blood level of Bartonella is often too low to see anything. To see anything, you need 2-6 weeks to grow it, “culture it.” If using basic red blood agar, it must be freshly made. These bacteria are intracellular, which makes visualization harder. What type of culture should you use to grow Bartonella quintana? Routine, vivid red blood agar? No.
Immense Challenges in Visualizing Bartonella Under a Microscope Continue »
Dr. Edward Breischwardt explained that dogs and humans have similar disease states with Bartonella. Dogs infected with Bartonella develop antibodies, and cutoff levels for a “positive” vary widely. But over approximately months, the antibodies drop into the negative range. This may be another reason Bartonella is so common yet tests negative via antibody testing. It really is just more example
A monkey study by Embers et al. published in 2012 provides compelling animal evidence for persistent infection as a mechanism for chronic Lyme disease. The study was conceived as an animal counterpart to the human trial by Klempner et al. that was published in 2001, and the monkeys were treated with a regimen of intravenous ceftriaxone (Rocephin) followed by oral
Lyme Disease Doctor Shows Chronic Persistent Infection Continue »
Arctigenin (AG) is a dibenzylbutyrolactone lignan found particularly in the fruit/seeds of Arctium lappa L. (burdock). It is the aglycone of arctiin. Mammalian research reports anti-inflammatory, neuroprotective, metabolic, anticancer, vascular, antiviral, and immunomodulatory actions. However, an important distinction is necessary: most therapeutic evidence is preclinical. Human interventional evidence is limited, with the most notable study involving an arctigenin-rich Arctium lappa
Arctigenin
Health-Benefit Research In Humans, Mice, Rats, And Other Mammalian Models Continue »
