These complex interleukins (IL) are inflammatory or proinflammatory. But if you put curcumin in special liposomal fatty coating or nano micelles that allow 100x the absorption you make get these effects.
Curcumin for intestinal IBD, arthritis, psoriasis, depression and atherosclerosis.
Reference
Rahimi HR, Nedaeinia R, Sepehri Shamloo A, Nikdoust S, Kazemi Oskuee R. Novel delivery system for natural products: Nano-curcumin formulations. Avicenna J Phytomed. 2016 Jul-Aug;6(4):383-98. PMID: 27516979; PMCID: PMC4967834.