Important quotes
1. They isolated the biofilm-like microcolony (MC) and planktonic (spirochetal form and round body) (SP) variant forms….
2. They were “more tolerant to the current Lyme antibiotics,” but [the biofilm Lyme bacteria] also caused more severe arthritis in mice….”
3. Only the combination of daptomycin, doxycycline, and ceftriaxone could kill the biofilm form.” I strongly believe the biofilm killing was done only by daptomycin.
4. Each form or variant requires different treatment. We have done this for over 25 years. “Variant forms” need different treatment.
SEE SCHALLER’S COMBATTING BIOFILMS THAT IS #1 ON THE TOPIC.
Feng J, Li T, Yee R, Yuan Y, Bai C, Cai M, Shi W, Embers M, Brayton C, Saeki H, Gabrielson K, Zhang Y. Stationary phase persister/biofilm microcolony of Borrelia burgdorferi causes more severe disease in a mouse model of Lyme arthritis: implications for understanding persistence, Post-treatment Lyme Disease Syndrome (PTLDS), and treatment failure. Discov Med. 2019 Mar;27(148):125-138. PMID: 30946803.