The best experts, half retired this year, used Coartem in various ways. Lumefantrine is half of Coartem.
“The activity of each individual drug was assessed in vitro against B. bovis. Five of the six antimalarial drugs assayed had activity against B. bovis… with the exception of lumefantrine, which showed NO activity up to 200 μM.
The most active drug was Methylene Blue, with an IC50 of 0.2 μM. The other drugs showed activity above 1 μM, varying between 9 μM (ARS) and 31 μM (TAF). While MEF, TAF, PRI and MB were able to kill all parasites at higher concentrations (above 20 μM).”
They add that artesunate had no detectable effect in this lab experiment.
Our Human Research in the Early-Middle 2000s Showed Artesunate Clearly Decreased Babesia in Red Blood Cells
Their conclusion included: “[We] found that the combination of artesunate-tafenoquine is a potential novel chemotherapeutic regimen.”
Reference
Carvalho LJM, Tuvshintulga B, Nugraha AB, Sivakumar T, Yokoyama N. Activities of artesunate-based combinations and tafenoquine against Babesia bovis in vitro and Babesia microti in vivo. Parasit Vectors. 2020 Jul 20;13(1):362. doi: 10.1186/s13071-020-04235-7. PMID: 32690081; PMCID: PMC7372749.