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Cymbalta Information

The FDA has approved Cymbalta for major depressive and diabetic peripheral neuropathic pain. It is promoted as being useful for depression and physical discomfort from depression. However, most antidepressants are believed to help pain to some degree.

Cymbalta affects both the serotonin and norepinephrine systems. Effexor does also, bit not as strongly on the norepinephrine system at lower doses. Serotonin and norepinephrine are both found naturally in the brain. This medication, Cymbalta, blocks the uptake of both of these chemicals.

Cymbalta comes in 20 mg, 30 mg and 60 mg capsules. The FDA and the makers seem to feel 60 mg is a common useful dose, but both understand that functional doses might be much less and much more. Dosing must be tailored to the patient carefully.

If you are started on to high a dose you might feel restless and require a dose reduction. If you are started on too small a dose and one that is ineffective, you might continue to be more and more depressed.

Therefore, the treatment of depression should not be sloppy and casual. The prescribing physician should have fairly close contact with you until your depression is gone. You and your family should watch you closely in the first few weeks of treatment. You should watch for suicidal thoughts, agitation, panic, ongoing or worsening depression, panic attacks, insomnia, irritability, aggressiveness or extreme hyperactivity. Any antidepressant, especially if started at too high a dose can cause mania in a vulnerable person. This can look like happy euphoria or a "high" appearance or extreme irritability.

Medical Problems that Require Extra Caution

  • Liver disease
  • Kidney disease
  • Narrow angle glaucoma
  • Diabetes
  • Regular or occasional alcohol use
  • Seizures
  • Mania or Bipolar disorder

Side Effects of Cymbalta

The possible side effects include:
  • dry mouth
  • nausea
  • constipation
  • decreased appetite
  • fatigue
  • sleepiness
  • increased sweating
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
  • an irregular heartbeat or pulse
  • low or high blood pressure–so your doctor may check your blood pressure
  • unusual bruising or bleeding
  • hives
  • fever
  • headache
  • changes in weight or appetite
  • constipation
  • decreased sex drive and functioning
  • sedation or insomnia

Overdose risk

An overdose can cause vomiting, tremor, agitation, seizures, drowsiness, hyperactivity, and enlarged pupils. Death is always possible.

Safety and Cymbalta

Anyone taking Cymbalta should understand you are at risk while driving, handling machines, or performing other hazardous activities such as working on tall ladders. Cymbalta can cause dizziness or drowsiness. If you experience dizziness or drowsiness, call your physician immediately and avoid activities that require complete alertness.

Alcohol can increase your risk of sedation and dangerous driving. Cymbalta can injure the liver.

Children and Adolescents

Antidepressants are not approved for use in children or adolescents. Yet some have massive depression and talk therapy and nutrients do not always work. Some feel physicians are monsters for treating children with these medications. But the reality is that some youth have high genetic loads for depression, which is one of the most common MEDICAL ILLNESSES in most countries in the world, and the other options do not work. I am happy to have a child do talk therapy and other treatments of a wide variety. But I am not going to ignore the 25 proofs of biological depression I have on this web site. When the PET scan shows depressed brains are biologically flawed, there is no point in denying the facts.

However, one study found that children and adolescents with depression did not commit suicide while involved in over 20 studies. However, on placebo pills 1 in 50 became suicidal, while 1 in 25 on antidepressants became suicidal. The cause of this is not proven. I suspect it might be partially due to excessive starting doses that make hopeless kids also agitated.

Stop Cymbalta Slowly

Like other antidepressants, Cymbalta should not be stopped suddenly if you have been on it for some time. Your brain receptors will adjust to it, and suddenly stopping can cause crying jags and agitation and dizziness, nausea or headache. Talk with your doctor or healthcare provider to work out a plan to slowly decrease your medication to avoid these symptoms.

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