JAMES SCHALLER, MD TOP DOCTOR 27 BOOKS BARTONELLA INSIGHTS NEW SPECIES LYME INFORMATION LYME INFO LYMENET ORG
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Lyme Info That Ignores Bartonella—Is It Complete Information?

Lyme Disease Information in 2010 Includes Close Reading of Bartonella and Study of Relapsing Bartonella Due to Routine Incomplete and Ineffective Treatments

In the recent past, "Lyme Experts" and many good labs reported that Bartonella was like a cold, a rare clinical issue, and something easily killed by one of six clique antibiotics listed in Lyme Disease books that merely skimmed and regurgitated over and over dubious relapse causing treatments.

Of course, no one speaking with such confidence to vulnerable patients and younger healers appeared to have read over 200 articles on this infection. Their unusual publication comments, "expert" treatments and positions on Bartonella showed the lack of soberness and work required to have any position on this deadly infection.

Some HIV and infection experts even reported the clearly false position that Bartonella was an infection mainly associated with immune compromised people. True, if you have not read over 10% of the literature, you might fall down this hole of false and simple thinking.

Immunocompromised patients are more likely to jump out at you if you just skim basic articles, but with careful and extensive reading, it has been clear for many years that Bartonella is a powerful infection and is exploding in numbers, species numbers and is a proven powerful cause of diverse and profound body damage.

Simply, it causes damage in many people all over the world, and hardly just the elderly, or children or those with HIV. If you spend your time treating and making income from a clinic seeing vast numbers of patients, you have no time to read the massive collection of information on this infection that is "emerging" but really has already emerged years ago.

In a medical mill, one can afford to pay malpractice premiums and make a good living with a revolving door using MD extenders--many people may be helped to some degree, but more mistakes will be made, and the healer will have no real time to read thousands of articles. Does this leave such a person possibly stuck in 1990 medicine?

Below we find a new species of Bartonella in healthy mice and it causes harm to many organs and is not a passing trivial cold. But if you are stuck in the 70's to 90's, Lyme is all alone in the belly of tick infection stew stomachs, and at best perhaps an occasional Babesia, Ehrlichia, Anaplasma or Mycoplasma may be present, along with a wide range of viruses.

Human isolates of Bartonella tamiae induce pathology in experimentally inoculated immunocompetent mice

Background

Bartonella tamiae, a newly described bacterial species, was isolated from the blood of three hospitalized patients in Thailand. These patients presented with headache, myalgia, anemia, and mild liver function abnormalities. Since B. tamiae was presumed to be the cause of their illness, these isolates were inoculated into immunocompetent mice to determine their relative pathogenicity in inducing manifestations of disease and pathology similar to that observed in humans.

Methods

Three groups of four Swiss Webster female mice aged 15-18 months were each inoculated with 106-7 colony forming units of one of three B. tamiae isolates [Th239, Th307, and Th339]. A mouse from each experimental group was sampled at 3, 4, 5 and 6 weeks post-inoculation. Two saline inoculated age-matched controls were included in the study. Samples collected at necropsy were evaluated for the presence of B. tamiae DNA, and tissues were formalin-fixed, stained with hematoxylin and eosin, and examined for histopathology.

Results

Following inoculation with B. tamiae, mice developed ulcerative skin lesions and subcutaneous masses on the lateral thorax, as well as axillary and inguinal lymphadenopathy. B. tamiae DNA was found in subcutaneous masses, lymph node, and liver of inoculated mice. Histopathological changes were observed in tissues of inoculated mice, and severity of lesions correlated with the isolate inoculated, with the most severe pathology induced by B. tamiae Th239. Mice inoculated with Th239 and Th339 demonstrated myocarditis, lymphadenitis with associated vascular necrosis, and granulomatous hepatitis and nephritis with associated hepatocellular and renal necrosis. Mice inoculated with Th307 developed a deep dermatitis and granulomas within the kidneys.

Conclusions

The three isolates of B. tamiae evaluated in this study induce disease in immunocompetent Swiss Webster mice up to 6 weeks after inoculation. The human patients from whom these isolates were obtained had clinical presentations consistent with the multi-organ pathology observed in mice in this study. This mouse model for B. tamiae induced disease not only strengthens the causal link between this pathogen and clinical illness in humans, but provides a model to further study the pathological processes induced by these bacteria.

Leah Colton, Nordin Zeidner , Tarah Lynch and Michael Y Kosoy

BMC Infectious Diseases 2010, 10:229


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