Coartem® for Babesia Treatment
This medication is a combination of artemether and lumefantrine. People familiar with Babesia and malaria medications will see immediately that the artemeter is a synthetic derived from sweet wormwood or Artemisia. Please note this is sweet wormwood not wormwood.
I am not aware of any article on Coartem or lumefantrine with Babesia. Like Mepron, lumefantrine is most effective when taken with fatty food, according to Nosten. It was invented in China in the 1980’s, and was found to fail in child treatment of malaria when the dose is low. But now it is a standard to treat malaria in areas of high resistance to conventional anti-malarials.
The current form is called “Coartem” with each Coartem tablet contains 20 mg artemether and 120 mg lumefantrine. Artemether has a rapid onset of action and is rapidly eliminated, whereas lumefantrine is eliminated over many days. Some side effects are not told to patients, such as rapid heart rates, a feeling of needing deeper breaths and cardiac side effects in those already vulnerable to heart trouble.
Coartem® was approved for the treatment of adults and children (>5 kg bodyweight) with uncomplicated malaria early as 1999 by the regulatory authorities of Switzerland and the EU.
On April 8, 2009, the U.S. Food and Drug Administration (FDA) announced that Coartem was approved for adults and children weighing at least five kilograms (just over ten pounds).
F. Nostren, P Phillips-Howard, F. ter Kuile. Other 4-Methanolquinolines, Amyl Alcohols and Phentathrenes: Mefloquine, Lumefantrine and Halofantine. InTreatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use. Springer: 2012.