Dr James Schaller
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THE COMMON MOLD TOXIN TRICHOTHECENE

I am regularly surprised at the incompetent government agencies, which say mold merely bothers the sinuses and lungs and that the hundreds of mold toxins are otherwise simply precious and safe. I think we need to improve the oxygen flow in these buildings. Their dinosaur medicine is hurting at least hundreds of thousands and likely millions.

T-2 or trichothecene is a fairly common toxic chemical produced by fusarium mold species, the famous black mold called, stachybotrys, trichoderma and other molds. They may contaminate food or feed grains, induce hemorrhage in lungs and brain, and damage bone marrow due to protein and DNA synthesis inhibition. So much for dangerous nonsense about merely troubling the sinuses!

T-2 is like many other mold toxins, called mycotoxins, which may enter your body through skin, your intestines from eating or deep in your lungs from breathing. They do not sit around for months to have effects on you, but quickly inhibitor protein and nucleic acid manufacturing. They particularly damage tissues, which grow fast like bone marrow, skin and mouth/nose/vagina, and other moist tissue.

If T-2 were used in war, the T-2 would stick to skin and go right through it! Other T-2 molecules would be eaten and inhaled. If you enter any moldy location with T-2, your papers, brief case, and clothing would be contaminated. If you go to another building or visit your children at school -- you just contaminated the school. At night, when you return to home, you would bring home the T-2 and it would serve as a reservoir for further toxin exposure.

SIGNS OF EXPOSURE

In minutes, I have had patients have many possible symptoms:

  • burning skin pain
  • ice-pick pain
  • red skin
  • tenderness
  • blistering
  • red eyes
  • itchy
  • blisters
  • painful nose
  • sneezing
  • running nose
  • coughing
  • wheezing
  • shortness of breath
  • blood streak in saliva or nasal mucous
  • Lost appetite
  • Nausea or vomiting
  • watery or blood tinged diarrhea (black stool can be digested blood)
  • abdominal cramps
  • eye pain,
  • eye tearing -- as if something in your eye
  • blurred vision

In contrast to silly government comments,
T-2 affects still more full bodily organs:

  • full body weakness
  • trouble walking
  • dizziness
  • lost coordination--which can be tested by seeing if you can stay on your feet with eyes closed, feet about 15 inches apart and with gentle pushes by the physician.
  • Rapid pulse
  • Low temperature
  • Jerky movements
  • Low blood pressure

Skin can rot off, slide off, and blood pressure can crash in individuals who die from T-2. Death is in minutes to days. So much for the government saying this is merely causing sinus and lung annoyance. At the same time some agencies say it is not too serious, the government military is preparing for the use of T-2 in biowarfare, designing decontamination kits, and warning of yellow rain as a possible T-2 attack.

DIAGNOSIS

In contrast to mustard gas, which has an odor and takes hours to hurt you, T-2 acts in minutes with no odor. One reason depending on a "mold" contractor's nose to determine if you have mold is utterly ridiculous.

Diagnosis of T-2 mycotoxins comes from blood and environmental samples tested with special GL-MS. This lab test can discover as little as 0.1 parts per billion. So human detection is blood or air. It appears to me the fastest testing is of T-2 in cereals.

TREATMENT

  1. Removal from the mold source is not an option. This includes moldy homes, work, schools, cars, garages, basements and any other source. Get a doctor's note.
  2. Pharmaceutical charcoal should be given orally.
  3. Some research shows that cholestyramine 5x a day on an empty stomach may be helpful.
  4. Clothing should be washed and soaked in 5% hypochlorite for 12 hours.
  5. Wash body thoroughly with soap and water -- 3x. This is not felt to be a waste of time, but very helpful.
  6. Wash eyes with sterile saline like that used in contact lens care.
  7. Consider full body charcoal powder which can be purchased many places including 610 363 7474 which carries a prescription super fine charcoal powder we use in first 90 seconds of fire ant toxins and also to clean our pool. It might help weaken T-2 on your skin. No promises.

See "Medical Management of Biological Casualties - Handbook." USAMRIID. Ft. Detrick, Fredrick, MD, 9/99 for more data.

TISSUES HURT THE MOST

T-2 inhibits protein synthesis.

Protein synthesis is essential to life. Period. Very active cells that are turning over new cells fast are very vulnerable. These include:

  • **the lining of the 30-foot gut
  • **the bone marrow which constantly makes red cells and infection fighting white cells
  • **the immune systems active lymph nodes and active spleen
  • **the liver, which is the massive cleaner of the blood and detoxifier of the blood

ANIMALS AS EXAMPLES OF SERIOUSNESS

I am not addressing her the issue of animals used in science, but only that clear levels have been found for the animals to become sick. The route matters a great deal -- inhaled is far worse that skin contact. Also, much of our animal knowledge comes from accidental exposure of domestic animals.

In 2001 there was a sudden and dramatic increase in the incidence of spontaneous abortions and early deaths of mares and foals in the state of Kentucky and surrounding states. The catastrophe was called Mare Reproductive Loss Syndrome (MRLS).

Many scientists think mycotoxins are the cause. For example, at the University of Kentucky's, Gluck Equine Research Centre, researchers have found levels of T2 toxin and the estrogenic mycotoxin zearalenone at quite high levels.

BIOWARFARE BOTTOM LINE

The Russian military discovered T-2 as biological toxins shortly after World War II, when civilians ate bread baked from flour contaminated with species of fusarium mold. Some victims developed a protracted lethal illness characterized by initial symptoms of abdominal pain, diarrhea, vomiting, and exhaustion followed within days by fever, chills, muscular pain, and an imbalance of the red and white blood cells accompanied by pus-forming or other disease-causing organisms or their toxins in the blood or tissues. And Iraq is well known to have researched T-2.

DO THES T-2 TOXINS HURT THE BRAIN,
HEART AND CARTILEGE?

These studies speak for themselves:


Toxicon. 1988;26(10):923-30.

Cerebral toxicity of the trichothecene toxin T-2, of the products of its hydrolysis and of some related toxins.

Bergmann F, Soffer D, Yagen B.

Department of Pharmacology, Hebrew University-Hadassah Medical School, Jerusalem.

T-2 toxin and its metabolites (resulting from enzymatic hydrolysis by rat brain homogenate) were applied to the midbrain of albino rats, either in solid form or dissolved in dimethyl sulfoxide (DMSO). Solid implants of HT-2 toxin and of T-2 triol were lethal in the range of 10-20 micrograms per rat, i.e. similar to the effect of T-2 toxin itself. For four further trichothecenes, the following decreasing order of toxicities was found: T-2 tetraol = iso-T-2 toxin greater than T-2 tetraol tetraacetate greater than T-2 toxin acetate. Implants of the last compound were the least toxic in the present series of trichothecenes; its LD50 value was nearly ten times higher than that of T-2 toxin. A similar gradation of toxicity was observed upon intracerebral injection of the compounds dissolved in DMSO. Here the only exception was the markedly reduced toxicity of T-2 toxin itself. From these data, the role of free 3 alpha- and 4 beta-hydroxyl groups has been evaluated. For subcutaneous applications, the largest ratio of LD50 values was 5, i.e. for the pair T-2 triol-T-2 tetraol tetraacetate. Among the signs of central intoxication, convulsions, adipsia and aphagia were marked. Pathological changes in the brain tissue, mainly involving necrotic, hemorrhagic and inflammatory lesions at the sites of application, were similar for all trichothecenes tested in this study.

PMID: 3201481 [PubMed - indexed for MEDLINE]


Zhonghua Yu Fang Yi Xue Za Zhi. 1996 May;30(3):141-3.

[Studies on relationship between toxicity of trichothecene toxin T-2 and its structure]

[Article in Chinese]

Peng S, Dong J, Yang J.

Institute of Toxicology and Pharmacology Academy of Military Medical Sciences, Beijing.

Toxic action of mycotoxin T-2 and its metabolite T-2 tetraol and deepoxy T-2; tetraol was studied by cytotoxicity and animal toxicity tests to explore the relationship between toxin T-2 and its structure. Restults showed that proliferation of LLC-PK1 cells and synthesis of DNA could be inhibited by both toxin T-2 and T-2 tetraol. Toxicity of toxin T-2 was 100 times greater than that of T-2 tetraol. There was no obvious toxicity to the proliferation of LLC-PK1 cells and synthesis of DNA in a dose of 10 mg/L deepoxy T-2 tetraol. But, toxin T-2 caused obvious damage in heart muscle and articular cartilage of chicken embryos, and T-2 tetraol and deepoxy T-2 tetraol in heart muscle, but not in articular cartilage. T-2 tetraol produced by hydrolysis of toxin T-2 had toxicity to certain extent, but its strength was significantly less than that of the latter. It suggests that the epoxide group in toxin T-2 played a determinant role for its toxicity. If epoxy cycle of the basic nucleus of the molecule is open, its toxicity will change significantly.

PMID: 9208522 [PubMed - indexed for MEDLINE]


My Best!

Dr. J



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