Dr James Schaller
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Mold and Nutritional Treatments

I recently met a health care practitioner who cannot prescribe traditional medications. I had once consulted with this person and found they had significant biotoxin exposure, with massive interpersonal symptoms resulting from biotoxins. She explained to me she was going to fix her problem with "aggressive nutraceutical" treatment, and said it in a way as if I was clueless. Why bother mentioning I had multiple nutritional publications and had helped designed wholesale nutraceutical formulations, and advocated in leading medical newspapers for the use of advanced nutritional care. I had also turned down opportunities to make "super formulations," because I knew the mark up could not match wholesale pricing formulations. Since I was an MD what could I possibly know about nutrition and herbs?

This health care worker also seemed to feel I must not understand the detox workings of the liver, even though I had most books in print on the topic, and so she traveled to someone who used herbs in a manner well known to anyone in progressive medicine. I support the use of standardized quality herbs, but feel they can be offered as messianic, in the same way drug companies oversell and overstate the use of their products.

So this unfortunate health worker is still markedly ill after two years, and yet continues to tell me "all is well," as I see the biotoxins signs in her voice, thinking, personality and reactions. Some would say she is "too far gone." I hope some day they will be proved wrong.

I wish biotoxins from mold, Lyme, toxic algae and other sources could be removed with mere oral or IV nutrients, common liver detox agents and herbs. I have the top IV formulations for this purpose, and while they certainly help with health, I do not see biotoxin cures when my friends administer them.

One area that is unappreciated by so-called "natural nutrient doctors" is that zinc appears to have a role in Melanocyte stimulating hormone function. Specifically, biotoxins commonly reduce this critical hormone and Zinc appears to stimulate MSH receptors. So perhaps in patients with deficient MSH some high quality zinc might be useful. In a chapter on the key book on this topic by Cone, an entire chapter reports that Zinc appears to stimulate all five MSH receptors. While the FDA would forbid any disease prevention or health claim, it might be an area of interest to the many millions who have deficient MSH and do not even know it.

The article abstract below discusses the role of zinc as an enhancer of MSH function. This should not be a surprise since zinc has at least 200 body functions. The form some feel is highly absorbed is L-Opti Zinc and it is available at the published wholesale off my site. Please compare to any price found on any nutrient web site or any store. Also, any product that will not list the amounts and forms of their ingredients is not just hiding them for "proprietary " reasons, but they are hiding them from the eyes of people who can read dosing and quality. Standardized herbs are very expensive and so are high absorption patented nutrients.

J Biol Chem. 2002 Dec 6;277(49):47662-70. Epub 2002 Sep 18.

Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors.

Holst B, Elling CE, Schwartz TW.

Laboratory for Molecular Pharmacology, Institute of Pharmacology, University of Copenhagen, The Panum Institute, Blegdamsvej 3, Copenhagen DK-2200, Denmark. b.holst@molpharm.dk

An endogenous metal-ion site in the melanocortin MC1 and MC4 receptors was characterized mainly in transiently transfected COS-7 cells. ZnCl(2) alone stimulated signaling through the Gs pathway with a potency of 11 and 13 microm and an efficacy of 50 and 20% of that of alpha-melanocortin stimulating hormone (alpha-MSH) in the MC1 and MC4 receptors, respectively. In the presence of peptide agonist, Zn(II) acted as an enhancer on both receptors, because it shifted the dose-response curves to the left: most pronounced was a 6-fold increase in alpha-MSH potency on the MC1 receptor. The effect of the metal ion appeared to be additive, because the maximal cAMP response for alpha-MSH in the presence of Zn(II) was 60% above the maximal response for the peptide alone. The affinity of Zn(II) could be increased through binding of the metal ion in complex with small hydrophobic chelators. The binding affinities and profiles were similar for a number of the 2,2'-bipyridine and 1,10-phenanthroline analogs in complex with Zn(II) in the MC1 and MC4 receptors. However, the potencies and efficacies of the metal-ion complexes were very different in the two receptors, and close to full agonism was obtained in the MC1 receptor. Metal ion-chelator complexes having antagonistic properties were also found. An initial attempt to map the metal-ion binding site in the MC1 receptor indicated that Cys(271) in extracellular loop 3 and possibly Asp(119) at the extracellular end of TM-III, which are both conserved among all MC receptors, are parts of the site. It is concluded that the function of the MC1 and MC4 receptors can be positively modulated by metal ions acting both as partial agonists and as potentiators for other agonists, including the endogenous peptide ligand alpha-MSH at Zn(II) concentrations that could be physiological. Furthermore, the metal ion-chelator complexes may serve as leads in the development of novel melanocortin receptor modulators.

PMID: 12244039 [PubMed - indexed for MEDLINE]

[All bolding is mine]



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